The syntheses of 1-N-((S)-4-amino-2-hydroxybutyryl)gentamicin C1 and 1-N-((S)-3-amino-2- hydroxypropionyl)gentamicin C1.
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منابع مشابه
The syntheses and biological properties of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B.
The syntheses of 1-N-(S-4-amino-2-hydroxybutyryl)-gentamicin B and 1-N-(S-3-amino-2-hydroxypropionyl)-gentamicin B, designated sch 20287 and Sch 21420, respectively, by procedures similar to those developed by KAWAGUCHI and co-workers for the transformation of kanamycin A to amikacin are described. The in vitro microbiological properties of Sch 20287 and Sch 21420 are compared with amikacin, ge...
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N, N΄-3, 4-di(methylamino)-1, 2, 5-oxadiazole (1f) was prepared by dehydration of N, N΄-3, 4-di(methylamino)glyoxime (2f) in aqueous potassium hydroxid at 170-180 ˚C. Under similar conditions N, N΄-3, 4-di(benzylamino)-1, 2, 5-oxadiazole (1c) and N, N΄-3, 4-di(isopropylamino)...
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The title compound, C(20)H(27)NOS, was obtained from the corresponding O-thio-carbamate. The structure features a C=O bond distance of 1.209 (2) Å and an sp(3)-hybridized S atom [C-S-C = 101.66 (1)°]. The steric bulk of the 1-adamantyl substituent on the 2-position of the aromatic ring is reflected in the S-C-C-C torsion angle [-7.5 (3)°].
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1974
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.27.889